Oksitosin

Oksitosin
Nama sistematis (IUPAC)
	1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oksoetil)-10-(3-amino-3-oksopropil)-16-(4-hidroksibenzil)-13-[(1S)-1-metilpropil]-6,9,12,15,18-pentaokso-1,2-dithlia-5,8,11,14,17-pentaazasikloikosan-4-yl}karbonil)-L-prolil-L-leusilglisinamida
Data klinis
Nama dagang	Decatosin, Induxin, Oxyla, Pitogin, Santocyn
Kat. kehamilan	?
Status hukum	?
Data farmakokinetik
Ikatan protein	30%
Metabolisme	Hati dan oksitosinase lainnya
Waktu paruh	1–6 menit (IV); ~2 h (intranasal)
Ekskresi	Empedu dan ginjal
Pengenal
Nomor CAS	50-56-6
Kode ATC	H01BB02
PubChem	CID 439302
Ligan IUPHAR	2174
DrugBank	DB00107
ChemSpider	388434
UNII	1JQS135EYN
KEGG	D00089
ChEBI	CHEBI:7872
ChEMBL	CHEMBL395429
Data kimia
Rumus	C43H66N12O12S2
SMILES	eMolecules & PubChem
	InChI InChI=1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1 ; Key:XNOPRXBHLZRZKH-DSZYJQQASA-N ;

Oksitosin (bahasa Yunani: (ŏk'sĭ-tō'sĭn), kelahiran cepat) (bahasa Inggris: oxytocin, OT, pitocin, syntocinon) adalah hormon pada manusia yang berfungsi untuk merangsang kontraksi yang kuat pada dinding rahim/uterus sehingga mempermudah dalam membantu proses kelahiran. Selain itu, Hormon ini juga berfungsi untuk mensekresi air susu dengan merangsang kontraksi duktus laktiferus kelenjar mammae (payudara) pada ibu menyusui. Namun, produksi air susu tersebut diatur oleh hormon prolaktin.

Prekursor oksitosin bernama oksitosin-neurofisin bahasa Inggris: oxytosin-neurophysin, OT-Np) disintesa di dalam kelenjar hipotalamus.^[3]

Referensi

^ Weisman O, Zagoory-Sharon O, Feldman R (September 2012). "Intranasal oxytocin administration is reflected in human saliva". Psychoneuroendocrinology. 37 (9): 1582–1586. doi:10.1016/j.psyneuen.2012.02.014. PMID 22436536. S2CID 25253083.
^ Huffmeijer R, Alink LR, Tops M, Grewen KM, Light KC, Bakermans-Kranenburg MJ, Ijzendoorn MH (2012). "Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration". Neuro Endocrinology Letters. 33 (1): 21–25. PMID 22467107.
^ (Inggris) "Oxytocin antiserum" (PDF). Sigma-Aldrich. Diakses tanggal 2010-02-26.^{[pranala nonaktif permanen]}

Pranala luar

Caldwell, H.K. and Young, W.S., III. Oxytocin and Vasopressin: Genetics and Behavioral Implications in Lim, R. (ed.) Handbook of Neurochemistry and Molecular Neurobiology, 3rd edition, Springer, New York, pp. 573–607, 2006. 320kb PDF
NewScientist.com - 'Release of Oxytocin due to penetrative sex reduces stress and neurotic tendencies', New Scientist (January 26, 2006)
Oxytocin.org Diarsipkan 2010-02-09 di Wayback Machine. - 'I get a kick out of you: Scientists are finding that, after all, love really is down to a chemical addiction between people', The Economist (February 12, 2004)
SMH.com.au - 'To sniff at danger: Inhalable oxytocin could become a cure for social fears', Boston Globe (January 12, 2006)
Hug the Monkey - A weblog devoted entirely to oxytocin
Oxytocin and understanding other minds
(Indonesia) Takdir Ditulis Dengan Tinta Oksitosin Dicetak Dalam Kitab Gen^{[pranala nonaktif permanen]}

Artikel bertopik biokimia ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[pmid22436536-1] Weisman O, Zagoory-Sharon O, Feldman R (September 2012). "Intranasal oxytocin administration is reflected in human saliva". Psychoneuroendocrinology. 37 (9): 1582–1586. doi:10.1016/j.psyneuen.2012.02.014. PMID 22436536. S2CID 25253083.

[pmid22467107-2] Huffmeijer R, Alink LR, Tops M, Grewen KM, Light KC, Bakermans-Kranenburg MJ, Ijzendoorn MH (2012). "Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration". Neuro Endocrinology Letters. 33 (1): 21–25. PMID 22467107.

[3] (Inggris) "Oxytocin antiserum" (PDF). Sigma-Aldrich. Diakses tanggal 2010-02-26.^{[pranala nonaktif permanen]}

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Pengawasan otoritas
Umum	Integrated Authority File (Jerman)
Perpustakaan nasional	Amerika Serikat Republik Ceko
Lain-lain	Faceted Application of Subject Terminology Microsoft Academic