p53

Tumor suppressor p53 trimer + DNA fragment, Human.

p53 (bahasa Inggris: protein 53, p53) adalah faktor transkripsi yang mendapat julukan dalam bahasa Inggris sebagai "the guardian of the genome", atau "guardian angel gene", dan "master watchman" karena peran protein tersebut dalam menjaga sel dari mutasi genetik akibat kerusakan DNA.

p53 memiliki ekspresi yang beragam seperti berbagai fungsi seluler, regulasi, apoptosis, replikasi DNA, proliferasi, dll. Dalam kondisi normal, jumlah konsentrasi p53 dalam sitoplasma sangat sedikit dan hanya teraktivasi saat sel mengalami stress.^[1]

Rendahnya asupan asam folat dan vitamin B6 dapat meningkatkan risiko mutasi genetik pada p53 dan menginduksi kanker usus besar.^[2] Upregulasi p53 yang berlebihan, biasanya terjadi pada kasus kemoterapi kanker dengan penggunaan cisplatin, dapat meracuni ginjal, dan perlu diturunkan segera, misalnya dengan penggunaan pifithrin-α.^[3]

Rujukan

^ (Inggris) "Watching the watcher: regulation of p53 by mitochondria". Graduate Center for Toxicology, University of Kentucky; Aaron K Holley dan Daret K St Clair. Diakses tanggal 2010-11-19.
^ (Inggris) "FOLATE AND VITAMIN B6 INTAKE AND RISK OF COLON CANCER IN RELATION TO P53 MUTATIONAL STATUS". Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Ludwig Boltzmann-Institute for Applied Cancer Research, KFJ-Spital, Vienna, Austria and Applied Cancer Research - Institute for Translational Research Vienna (ACR–ITR VIEnna), Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Department of Medical Oncology, Dana-Farber Cancer Institute; Eva S. Schernhammer, MD, DrPH, Shuji Ogino, MD, PhD, dan Charles S. Fuchs, MD, MPH. Diakses tanggal 2010-12-12.
^ (Inggris) "Activation and involvement of p53 in cisplatin-induced nephrotoxicity" (PDF). Department of Cellular Biology and Anatomy, Medical College of Georgia and Veterans Affairs Medical Center, Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Department of Internal Medicine, University of Arkansas for Medical Sciences; Qingqing Wei, Guie Dong, Tianxin Yang, Judit Megyesi, Peter M. Price, dan Zheng Dong. Diakses tanggal 2010-12-12.

Artikel bertopik genetika ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[1] (Inggris) "Watching the watcher: regulation of p53 by mitochondria". Graduate Center for Toxicology, University of Kentucky; Aaron K Holley dan Daret K St Clair. Diakses tanggal 2010-11-19.

[2] (Inggris) "FOLATE AND VITAMIN B6 INTAKE AND RISK OF COLON CANCER IN RELATION TO P53 MUTATIONAL STATUS". Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Ludwig Boltzmann-Institute for Applied Cancer Research, KFJ-Spital, Vienna, Austria and Applied Cancer Research - Institute for Translational Research Vienna (ACR–ITR VIEnna), Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Department of Medical Oncology, Dana-Farber Cancer Institute; Eva S. Schernhammer, MD, DrPH, Shuji Ogino, MD, PhD, dan Charles S. Fuchs, MD, MPH. Diakses tanggal 2010-12-12.

[3] (Inggris) "Activation and involvement of p53 in cisplatin-induced nephrotoxicity" (PDF). Department of Cellular Biology and Anatomy, Medical College of Georgia and Veterans Affairs Medical Center, Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Department of Internal Medicine, University of Arkansas for Medical Sciences; Qingqing Wei, Guie Dong, Tianxin Yang, Judit Megyesi, Peter M. Price, dan Zheng Dong. Diakses tanggal 2010-12-12.

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